SC66 | Akt 抑制剂 | MCE

来自 : www.medchemexpress.cn/SC66.htm 发布时间：2021-03-25

SC66 inhibits cell viability and colony forming capacity of HCC cells with IC50s of 0.77，0.47，0.92，0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5，HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC50s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

= × × Keywords: SC66SC 66SC-66AktApoptosisPKBProtein kinase BInhibitorinhibitorinhibit 您最近查看的产品: SC66 sales@MedChemExpress.cn 400-820-3792...SC66 | SC 66 | SC-66 | Akt | Apoptosis | PKB | Protein kinase B | Inhibitor | inhibitor | inhibitSC66 是一种 Akt 抑制剂，降低细胞活力，这种作用存在剂量和时间依赖性，且抑制肝癌 (HCC) 细胞的集落形成和诱导凋亡。- 高纯度，全球文献引用。SC66